Pyoderma gangrenosum: challenges and solutions

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Pyoderma gangrenosum: challenges and solutions

Pyoderma gangrenosum (PG) is a rare disease, but commonly related to important morbidity. PG was first assumed to be infectious, but is now considered an inflammatory neutrophilic disease, often associated with autoimmunity, and with chronic inflammatory and neoplastic diseases. Currently, many aspects of the underlying pathophysiology are not well understood, and etiology still remains unknown...

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Pyoderma gangrenosum.

Pyoderma gangrenosum (PG) is an idiopathic, ulcerative, noninfective chronic inflammatory skin disorder of unknown etiology. It is associated with systemic medical illness in 50% of cases like inflammatory bowel disease, systemic arthritis, haematological diseases and malignancies. Characteristic lesions begin as pustule or vesiculopustule and progresses to an ulcer or deep erosion with violace...

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Ibrutinib-induced pyoderma gangrenosum.

710 started an oral ibrutinib therapy (3 × 140 mg/d), due to B-CLL. An ulcer biopsy revealed lymphocyte and neutrophil infiltration. No histopathologic signs of carcinoma or vasculitis were observed. After consultation with a hematologist, a tentative diagnosis of ibrutinib-induced pyoderma gangrenosum (PG) was established. In addition to ibrutinib discontinuation, daily prednisone dose was inc...

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Pyoderma gangrenosum – a review

Pyoderma gangrenosum (PG) is a rare noninfectious neutrophilic dermatosis. Clinically it starts with sterile pustules that rapidly progress and turn into painful ulcers of variable depth and size with undermined violaceous borders. The legs are most commonly affected but other parts of the skin and mucous membranes may also be involved. Course can be mild or malignant, chronic or relapsing with...

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Nicotine for pyoderma gangrenosum.

A 35-year-old man with no past medical illness developed bloody diarrhea with up to 12 loose stools per day and abdominal pain in February 1984. He had smoked 1 pack of cigarettes per day for 16 years until he stopped smoking 2 months prior to the onset of his illness. In March 1984, he was hospitalized because of toxic dilatation of the colon (toxic megacolon). Treatment consisted of intraveno...

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ژورنال

عنوان ژورنال: OncoTargets and Therapy

سال: 2015

ISSN: 1178-6930

DOI: 10.2147/ott.s61202